The MIT Press has been a leader in open access book publishing for over two decades, beginning in 1995 with the publication of William Mitchell’s City of Bits, which appeared simultaneously in print and in a dynamic, open web edition.

Professor Sian Harding - Emeritus Professor at Imperial College London. Previous Head of the Cardiovascular Division and Director of the British Heart Foundation Cardiovascular Regenerative Medicine Centre. Sian E. Harding currently holds the position of Professor of Cardiac Pharmacology at Imperial College London’s National Heart and Lung Institute. In this first week, we'll take time to get to know each other. Additionally, we'll be presented with an overview of machine learning techniques, dataset collection, speculative design concepts, critical discourse, and a brief introduction to Playform.Written in a conversational tone with elements of humour and personal anecdotes, making it an enjoyable and approachable read.

Experiments have even demonstrated that emotional states can change within a single resting heartbeat, emphasising the heart’s role in shaping our emotional responses. For example, during heart contraction, fear responses are amplified, while during heart relaxation, they are dampened. Such findings shed light on how our bodies, bypassing conscious cognitive processes, can swiftly respond to perceived threats, offering a potential advantage in moments of danger. Interestingly, responses to images of faces expressing disgust, happiness, or neutrality vary, underscoring the heart’s unique influence on specific emotional reactions, especially in the face of potential threats.

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The last couple chapters deal largely with the future of heart repair through genetic / biological means (as opposed to via mechanical hearts and technologies, which are dealt with in Chapter nine.) This is where the book gets to be a challenging read for a readership of non-experts. It gets technical and jargon- / acronym-heavy. The book reveals how carbon dating, a technique typically associated with archaeology, provided essential insights into the heart’s regeneration capabilities. It was discovered that around half of the cardiomyocytes in a 75-year-old person’s heart had been present throughout their entire life, attesting to the heart’s remarkable endurance. Although there is a small degree of regeneration, especially in younger individuals, it falls short in cases of severe cardiac disease. She observes that cancer and heart disease are inversely correlated. When oncologists cure cancer, heart disease often followers - and vice versa.

This lively account on recent advances in heart research stands out by its accessibility to a broader audience – I just loved her analogies to pastry or 'the heart as a city'!" At first, the papers being published on Takotsubo syndrome described these kinds of triggering incidents linked to disaster and grief. Often, the triggers were very like those for SCD, such as bereavement and trauma.” Elisabeth Ehler, Professor of Cardiac Cell Biology, King's College London, author of Cardiac Cytoarchitecture IF YOU LIVE IN THE EU AND HAVE A VAT NUMBER— IT IS VAT ZERO! WE ENCOURAGE EVERYONE TO HAVE AND PROVIDE THIS VAT TAX NUMBER. MIT Press Direct is a distinctive collection of influential MIT Press books curated for scholars and libraries worldwide.MIT Press began publishing journals in 1970 with the first volumes of Linguistic Inquiry and the Journal of Interdisciplinary History. Today we publish over 30 titles in the arts and humanities, social sciences, and science and technology. Offers a balanced perspective by discussing both the successes and failures of research, providing an authentic portrayal of scientific inquiry. Elisabeth Ehler, Professor of Cardiac Cell Biology, King's College London, author of Cardiac Cytoarchitecture

Sian Harding has been researching the causes of heart failure for 40 years, and has become more and more impressed at the astounding construction of the heart and its deep resilience. In fact, it is the very perfection of the heart that resists all our attempts to repair it, and is the challenge for the new technologies like gene therapy, tissue engineering or building a mechanical heart. Provides valuable insights into the heart and the current state of treating heart disease, making it informative for readers interested in the subject.In week two, we'll get into a deeper discussion and review of dataset collection. We'll begin initial training in Playform, have an brief introduction to GPT-2/J, and have conversations relating to manifests/words of importance for the future. Professor Harding talked about her successes and failures, and about the new threats to the heart as well as the new hopes for cardiac regeneration.